| Conferencia este | Par. | Pts | Goles | Dif | P.G. | P.E. | P.P. | |
|---|---|---|---|---|---|---|---|---|
| 1. | Nashville SC | 17 | 47 | 48:14 | 34 | 15 | 2 | 0 |
| 2. | New England Revolution | 17 | 35 | 31:20 | 11 | 11 | 2 | 4 |
| 3. | Charlotte FC | 17 | 34 | 37:16 | 21 | 10 | 4 | 3 |
| 4. | Orlando City | 17 | 33 | 33:22 | 11 | 10 | 3 | 4 |
| 5. | Cincinnati FC | 17 | 30 | 39:32 | 7 | 9 | 3 | 5 |
| 6. | Philadelphia Union | 17 | 29 | 32:19 | 13 | 8 | 5 | 4 |
| 7. | Columbus Crew | 17 | 29 | 29:19 | 10 | 9 | 2 | 6 |
| 8. | Chicago Fire | 17 | 29 | 33:25 | 8 | 9 | 2 | 6 |
| 9. | Inter Miami CF | 17 | 27 | 46:31 | 15 | 6 | 9 | 2 |
| 10. | Toronto FC | 17 | 27 | 36:33 | 3 | 6 | 9 | 2 |
| 11. | New York Red Bulls | 17 | 24 | 27:29 | -2 | 7 | 3 | 7 |
| 12. | New York City FC | 17 | 21 | 30:24 | 6 | 5 | 6 | 6 |
| 13. | D.C. United | 17 | 20 | 20:29 | -9 | 5 | 5 | 7 |
| 14. | CF Montreal | 17 | 17 | 19:25 | -6 | 4 | 5 | 8 |
| 15. | Atlanta United FC | 17 | 17 | 26:33 | -7 | 5 | 2 | 10 |
| Conferencia oeste | Par. | Pts | Goles | Dif | P.G. | P.E. | P.P. | |
|---|---|---|---|---|---|---|---|---|
| 1. | Vancouver Whitecaps | 17 | 35 | 44:16 | 28 | 11 | 2 | 4 |
| 2. | Colorado Rapids | 17 | 33 | 31:19 | 12 | 10 | 3 | 4 |
| 3. | Real Salt Lake | 17 | 33 | 33:22 | 11 | 10 | 3 | 4 |
| 4. | FC Dallas | 17 | 32 | 32:23 | 9 | 9 | 5 | 3 |
| 5. | Los Angeles FC | 17 | 31 | 32:18 | 14 | 9 | 4 | 4 |
| 6. | St. Louis City SC | 17 | 31 | 36:23 | 13 | 9 | 4 | 4 |
| 7. | Portland Timbers | 17 | 31 | 37:28 | 9 | 9 | 4 | 4 |
| 8. | Houston Dynamo | 17 | 29 | 19:15 | 4 | 8 | 5 | 4 |
| 9. | Seattle Sounders | 17 | 28 | 26:23 | 3 | 8 | 4 | 5 |
| 10. | Los Angeles Galaxy | 17 | 27 | 26:21 | 5 | 7 | 6 | 4 |
| 11. | San Jose Earthquakes | 17 | 26 | 30:26 | 4 | 7 | 5 | 5 |
| 12. | San Diego FC | 17 | 23 | 37:30 | 7 | 6 | 5 | 6 |
| 13. | Minnesota United FC | 17 | 22 | 25:22 | 3 | 5 | 7 | 5 |
| 14. | Austin FC | 17 | 18 | 22:25 | -3 | 4 | 6 | 7 |
| 15. | Sporting Kansas City | 17 | 14 | 24:35 | -11 | 3 | 5 | 9 |