| Conferencia este | Par. | Pts | Goles | Dif | P.G. | P.E. | P.P. | |
|---|---|---|---|---|---|---|---|---|
| 1. | Nashville SC | 34 | 77 | 71:25 | 46 | 23 | 8 | 3 |
| 2. | Inter Miami CF | 34 | 60 | 80:59 | 21 | 16 | 12 | 6 |
| 3. | New England Revolution | 34 | 58 | 55:47 | 8 | 18 | 4 | 12 |
| 4. | Chicago Fire | 34 | 55 | 64:54 | 10 | 16 | 7 | 11 |
| 5. | Charlotte FC | 34 | 54 | 66:51 | 15 | 15 | 9 | 10 |
| 6. | Philadelphia Union | 34 | 50 | 66:52 | 14 | 14 | 8 | 12 |
| 7. | Columbus Crew | 34 | 47 | 59:52 | 7 | 14 | 5 | 15 |
| 8. | Cincinnati FC | 34 | 46 | 67:75 | -8 | 12 | 10 | 12 |
| 9. | Orlando City | 34 | 46 | 63:78 | -15 | 13 | 7 | 14 |
| 10. | New York City FC | 34 | 42 | 49:45 | 4 | 10 | 12 | 12 |
| 11. | New York Red Bulls | 34 | 42 | 48:62 | -14 | 12 | 6 | 16 |
| 12. | Toronto FC | 34 | 39 | 52:67 | -15 | 9 | 12 | 13 |
| 13. | Atlanta United FC | 34 | 33 | 43:60 | -17 | 9 | 6 | 19 |
| 14. | D.C. United | 34 | 33 | 39:61 | -22 | 7 | 12 | 15 |
| 15. | CF Montreal | 34 | 26 | 37:69 | -32 | 6 | 8 | 20 |
| Conferencia oeste | Par. | Pts | Goles | Dif | P.G. | P.E. | P.P. | |
|---|---|---|---|---|---|---|---|---|
| 1. | Vancouver Whitecaps | 34 | 64 | 74:34 | 40 | 19 | 7 | 8 |
| 2. | FC Dallas | 34 | 58 | 62:51 | 11 | 16 | 10 | 8 |
| 3. | St. Louis City SC | 34 | 54 | 59:48 | 11 | 15 | 9 | 10 |
| 4. | San Jose Earthquakes | 34 | 52 | 57:51 | 6 | 14 | 10 | 10 |
| 5. | Houston Dynamo | 34 | 51 | 43:43 | 0 | 14 | 9 | 11 |
| 6. | Los Angeles FC | 34 | 47 | 52:40 | 12 | 12 | 11 | 11 |
| 7. | Portland Timbers | 34 | 46 | 62:61 | 1 | 13 | 7 | 14 |
| 8. | Seattle Sounders | 34 | 46 | 44:46 | -2 | 12 | 10 | 12 |
| 9. | Real Salt Lake | 34 | 45 | 53:52 | 1 | 13 | 6 | 15 |
| 10. | Minnesota United FC | 34 | 44 | 56:58 | -2 | 11 | 11 | 12 |
| 11. | Los Angeles Galaxy | 34 | 44 | 50:57 | -7 | 11 | 11 | 12 |
| 12. | Colorado Rapids | 34 | 43 | 47:50 | -3 | 12 | 7 | 15 |
| 13. | San Diego FC | 34 | 38 | 57:63 | -6 | 9 | 11 | 14 |
| 14. | Austin FC | 34 | 34 | 42:65 | -23 | 8 | 10 | 16 |
| 15. | Sporting Kansas City | 34 | 26 | 40:81 | -41 | 7 | 5 | 22 |