| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 16/09/22 2:15 | Kansas City Chiefs | Los Angeles Chargers | 27:24 |
| 18/09/22 19:00 | New York Giants | Carolina Panthers | 19:16 |
| 18/09/22 19:00 | Jacksonville Jaguars | Indianapolis Colts | 24:0 |
| 18/09/22 19:00 | Cleveland Browns | New York Jets | 30:31 |
| 18/09/22 19:00 | Detroit Lions | Washington Commanders | 36:27 |
| 18/09/22 19:00 | New Orleans Saints | Tampa Bay Buccaneers | 10:20 |
| 18/09/22 19:00 | Pittsburgh Steelers | New England Patriots | 14:17 |
| 18/09/22 19:00 | Baltimore Ravens | Miami Dolphins | 38:42 |
| 18/09/22 22:05 | San Francisco 49ers | Seattle Seahawks | 27:7 |
| 18/09/22 22:05 | Los Angeles Rams | Atlanta Falcons | 31:27 |
| 18/09/22 22:25 | Dallas Cowboys | Cincinnati Bengals | 20:17 |
| 18/09/22 22:25 | Denver Broncos | Houston Texans | 16:9 |
| 18/09/22 22:25 | Las Vegas Raiders | Arizona Cardinals | 23:29OT |
| 19/09/22 2:20 | Green Bay Packers | Chicago Bears | 27:10 |
| 20/09/22 1:15 | Buffalo Bills | Tennessee Titans | 41:7 |
| 20/09/22 2:30 | Philadelphia Eagles | Minnesota Vikings | 24:7 |