| Conferencia este | Par. | Pts | Goles | Dif | P.G. | P.E. | P.P. | |
|---|---|---|---|---|---|---|---|---|
| 1. | Nashville SC | 12 | 34 | 36:12 | 24 | 11 | 1 | 0 |
| 2. | New England Revolution | 12 | 26 | 22:11 | 11 | 8 | 2 | 2 |
| 3. | Charlotte FC | 13 | 25 | 26:13 | 13 | 7 | 4 | 2 |
| 4. | Cincinnati FC | 12 | 24 | 34:24 | 10 | 7 | 3 | 2 |
| 5. | Orlando City | 13 | 23 | 23:17 | 6 | 7 | 2 | 4 |
| 6. | Chicago Fire | 11 | 22 | 21:12 | 9 | 7 | 1 | 3 |
| 7. | Toronto FC | 14 | 20 | 29:28 | 1 | 4 | 8 | 2 |
| 8. | Philadelphia Union | 12 | 19 | 19:11 | 8 | 5 | 4 | 3 |
| 9. | Inter Miami CF | 12 | 18 | 33:24 | 9 | 4 | 6 | 2 |
| 10. | Columbus Crew | 13 | 17 | 17:15 | 2 | 5 | 2 | 6 |
| 11. | D.C. United | 13 | 17 | 17:23 | -6 | 4 | 5 | 4 |
| 12. | New York City FC | 13 | 16 | 26:20 | 6 | 4 | 4 | 5 |
| 13. | New York Red Bulls | 12 | 15 | 18:23 | -5 | 4 | 3 | 5 |
| 14. | CF Montreal | 12 | 14 | 16:15 | 1 | 3 | 5 | 4 |
| 15. | Atlanta United FC | 12 | 13 | 17:21 | -4 | 4 | 1 | 7 |
| Conferencia oeste | Par. | Pts | Goles | Dif | P.G. | P.E. | P.P. | |
|---|---|---|---|---|---|---|---|---|
| 1. | Vancouver Whitecaps | 13 | 28 | 31:9 | 22 | 9 | 1 | 3 |
| 2. | Colorado Rapids | 12 | 27 | 22:9 | 13 | 9 | 0 | 3 |
| 3. | Los Angeles FC | 13 | 26 | 25:11 | 14 | 8 | 2 | 3 |
| 4. | Houston Dynamo | 12 | 26 | 15:8 | 7 | 8 | 2 | 2 |
| 5. | St. Louis City SC | 12 | 24 | 25:16 | 9 | 7 | 3 | 2 |
| 6. | Portland Timbers | 13 | 24 | 31:24 | 7 | 7 | 3 | 3 |
| 7. | Real Salt Lake | 12 | 23 | 24:17 | 7 | 7 | 2 | 3 |
| 8. | San Diego FC | 13 | 21 | 32:19 | 13 | 6 | 3 | 4 |
| 9. | FC Dallas | 11 | 19 | 24:20 | 4 | 5 | 4 | 2 |
| 10. | Austin FC | 12 | 17 | 16:12 | 4 | 4 | 5 | 3 |
| 11. | San Jose Earthquakes | 12 | 17 | 20:19 | 1 | 5 | 2 | 5 |
| 12. | Los Angeles Galaxy | 13 | 17 | 15:16 | -1 | 4 | 5 | 4 |
| 13. | Seattle Sounders | 11 | 15 | 16:18 | -2 | 4 | 3 | 4 |
| 14. | Minnesota United FC | 12 | 12 | 12:13 | -1 | 2 | 6 | 4 |
| 15. | Sporting Kansas City | 12 | 12 | 15:22 | -7 | 3 | 3 | 6 |