| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 16/04/23 1:30 | Columbus Crew | New England Revolution | 1:1 |
| 16/04/23 1:30 | New York City FC | Nashville SC | 2:1 |
| 16/04/23 1:30 | New York Red Bulls | Houston Dynamo | 1:1 |
| 16/04/23 1:30 | Charlotte FC | Colorado Rapids | 2:2 |
| 16/04/23 1:30 | Toronto FC | Atlanta United FC | 2:2 |
| 16/04/23 1:30 | CF Montreal | D.C. United | 0:1 |
| 16/04/23 2:30 | FC Dallas | Real Salt Lake | 2:1 |
| 16/04/23 2:30 | Minnesota United FC | Orlando City | 1:2 |
| 16/04/23 2:30 | Chicago Fire | Philadelphia Union | 2:2 |
| 16/04/23 2:30 | St. Louis City SC | Cincinnati FC | 5:1 |
| 16/04/23 2:30 | Austin FC | Vancouver Whitecaps | 0:0 |
| 16/04/23 4:30 | San Jose Earthquakes | Sporting Kansas City | 3:0 |
| 16/04/23 4:30 | Portland Timbers | Seattle Sounders | 4:1 |
| 16/04/23 22:30 | Los Angeles Galaxy | Los Angeles FC | 2:3 |