| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 2/10/25 18:45 | FC Bologna | SC Freiburg | 1:1 |
| 2/10/25 18:45 | FCSB Bukarest | Young Boys Berna | 0:2 |
| 2/10/25 18:45 | Viktoria Pilsen | Malmö FF | 3:0 |
| 2/10/25 18:45 | Celtic Glasgow | Sporting Braga | 0:2 |
| 2/10/25 18:45 | Panathinaikos Athenas | Go Ahead Eagles Deventer | 1:2 |
| 2/10/25 18:45 | Fenerbahçe SK | OGC Niza | 2:1 |
| 2/10/25 18:45 | AS Roma | OSC Lille | 0:1 |
| 2/10/25 18:45 | Brann Bergen | FC Utrecht | 1:0 |
| 2/10/25 18:45 | PFC Ludogorets Razgrad | Real Betis Balompié | 0:2 |
| 2/10/25 21:00 | Feyenoord Rotterdam | Aston Villa | 0:2 |
| 2/10/25 21:00 | FC Porto | Estrella Roja Belgrado | 2:1 |
| 2/10/25 21:00 | FC Basilea | VfB Stuttgart | 2:0 |
| 2/10/25 21:00 | Olympique Lyon | FC Red Bull Salzburgo | 2:0 |
| 2/10/25 21:00 | KRC Genk | Ferencvaros Budapest | 0:1 |
| 2/10/25 21:00 | Maccabi Tel Aviv | Dinamo Zagreb | 1:3 |
| 2/10/25 21:00 | Nottingham Forest | FC Midtjylland | 2:3 |
| 2/10/25 21:00 | SK Sturm Graz | Glasgow Rangers | 2:1 |
| 2/10/25 21:00 | R. C. Celta de Vigo | PAOK Salónica | 3:1 |