Calendario
| Fecha | Fecha pronóstico | Local | Visitante | Resultado | Regla de puntos |
|---|---|---|---|---|---|
| 25/11/21 18:30 | 25/11/21 18:30 | Detroit Lions | Chicago Bears | 14:16 | 5 - 10 - 3 |
| 25/11/21 22:30 | 25/11/21 22:30 | Dallas Cowboys | Las Vegas Raiders | 33:36OT | 3 - 10 - 10 |
| 26/11/21 2:20 | 26/11/21 2:20 | New Orleans Saints | Buffalo Bills | 6:31 | 6 - 10 - 3 |
| 28/11/21 19:00 | 28/11/21 19:00 | Jacksonville Jaguars | Atlanta Falcons | 14:21 | 4 - 10 - 4 |
| 28/11/21 19:00 | 28/11/21 19:00 | Cincinnati Bengals | Pittsburgh Steelers | 41:10 | 4 - 10 - 5 |
| 28/11/21 19:00 | 28/11/21 19:00 | New England Patriots | Tennessee Titans | 36:13 | 3 - 10 - 6 |
| 28/11/21 19:00 | 28/11/21 19:00 | Miami Dolphins | Carolina Panthers | 33:10 | 5 - 10 - 4 |
| 28/11/21 19:00 | 28/11/21 19:00 | New York Giants | Philadelphia Eagles | 13:7 | 8 - 10 - 3 |
| 28/11/21 19:00 | 28/11/21 19:00 | Houston Texans | New York Jets | 14:21 | 3 - 10 - 7 |
| 28/11/21 19:00 | 28/11/21 19:00 | Indianapolis Colts | Tampa Bay Buccaneers | 31:38 | 5 - 10 - 4 |
| 28/11/21 22:05 | 28/11/21 22:05 | Denver Broncos | Los Angeles Chargers | 28:13 | 8 - 10 - 3 |
| 28/11/21 22:25 | 28/11/21 22:25 | San Francisco 49ers | Minnesota Vikings | 34:26 | 4 - 10 - 4 |
| 28/11/21 22:25 | 28/11/21 22:25 | Green Bay Packers | Los Angeles Rams | 36:28 | 4 - 10 - 4 |
| 29/11/21 2:20 | 29/11/21 2:20 | Baltimore Ravens | Cleveland Browns | 16:10 | 3 - 10 - 8 |
| 30/11/21 2:15 | 30/11/21 2:15 | Washington Football Team | Seattle Seahawks | 17:15 | 4 - 10 - 4 |